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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Therapeutic effects of adipose-derived mesenchymal stem/stromal cells with enhanced migration ability and hepatocyte growth factor secretion by low-molecular-weight heparin treatment in bleomycin-induced mouse models of systemic sclerosis

Fig. 6

Genes related to fibrosis in skin were regulated by administering hep-mASCs. The skin mRNA expression levels of α-SMA, TGF-β1, and COL1α1 were significantly downregulated in the BLM-mASC group, the BLM-hep10-mASC group, and the BLM-hep100-mASC group when compared to those in the BLM-only group. The skin mRNA expression levels of TIMP-2 were significantly downregulated in the BLM-hep10-mASC and BLM-hep100-mASC groups when compared to those in the BLM-only group, but were not downregulated in the BLM-mASC group. n = 7 in each group. Data are shown as mean ± SEM. *P < 0.05; **P < 0.01 vs. BLM-alone group

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Arthritis Research & Therapy

ISSN: 1478-6362

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