Fig. 1
From: Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
SAMP8 exhibit normal skeletal development and knee joint. A Full-body photographs of SAMR1 and SAMP8 were captured at 4 weeks of age (n = 10 for each strain). No significant difference in body length was observed. B Body weight of SAMP8 was changed with aging from 3 to 33 weeks of age (n = 10 for each strain). Data of body weight was analyzed by two-way factorial ANOVA. C Safranin O/Fast Green staining and type X Collagen staining in growth plate at 4 weeks of age. D Menisci structural images were obtained from SAMR1 and SAMP8 at 4 weeks of age. E, F Cellularity in articular cartilage surface at 4 weeks of age. Cartilage thickness of each part is the average thickness from horizontal quinque-section points over three different sections of one sample. Data represented as mean ± S.D. Comparison of mean values was performed using Welch’s t test. #P < 0.05, ##P < 0.01 versus SAMR1. FC: Femoral condyle, TP: Tibial plateau