Fig. 6
From: Senescence-accelerated mice prone 8 (SAMP8) in male as a spontaneous osteoarthritis model
Pathological changes in ankle and hip joints in SAMP8 with aging. A Safranin O staining of the knee, hip and ankle joints in SAMR1 and SAMP8 at 23 weeks of age. B, C Immunohistochemistry using anti-type X Collagen on hip and ankle joints from SAMR1 and SAMP8 at 23 weeks of age. D, E Immunohistochemistry using anti-p16INK4a antibodies on hip and ankle joints from SAMR1 and SAMP8 at 23 weeks of age (ankle and hip: n = 5 for each strain). All data represented as mean ± S.D. Comparison of mean values was performed using the Welch’s t test; #P < 0.05 versus SAMR1