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Table 4 Comparison in peripheral blood immune phenotypes between PAO (n=22), PsA (n=33), and HCs (n=30)

From: Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes

 

HC

PsA

PAO

p value

HC vs PsA

HC vs PAO

PsA vs PAO

CD4+ T cells

 Naive

55.7 (43.5, 61.3)

49.2 (32.3, 60.0)

51.6 (45.0, 63.2)

0.8780

1.0000

0.9810

 Central memory

34.4 (25.3, 41.7)

32.8 (24.6, 44.6)

31.5 (23.0, 37.8)

1.0000

1.0000

1.0000

 Effector memory

11.1 (6.8, 15.6)

10.1 (7.4, 17.8)

10.0 (6.5, 14.9)

1.0000

1.0000

1.0000

 TEMRA

2.4 (1.5, 4.0)

3.2 (2.1, 4.7)

2.5 (1.5, 4.6)

0.2980

1.0000

0.6955

 Th1

17.7 (13.1, 26.0)

20.5 (17.0, 24.4)

17.8 (12.3, 19.8)

0.6549

1.0000

0.1041

 Th17

9.8 (7.6, 12.8)

10.9 (9.1, 14.7)

12.1 (9.3, 16.6)

0.8311

0.1874

1.0000

 Treg

4.6 (3.8, 5.6)

4.7 (3.6, 5.7)

4.3 (3.3, 5.7)

1.0000

1.0000

1.0000

 Tfh

0.8 (0.7, 1.4)

0.7 (0.3, 1.4)

0.8 (0.7, 1.1)

0.6043

1.0000

0.8582

CD8+ T cells

 Naive

40.7 (24.9, 54.9)

44.4 (34.5, 56.2)

34.4 (29.2, 49.7)

1.0000

1.0000

0.3747

 Central memory

8.2 (4.9, 28.5)

17.1 (9.7, 26.9)

19.9 (13.4, 29.3)

0.2300

0.1120

1.0000

 Effector memory

12.9 (9.0, 27.5)

9.8 (5.3, 19.8)

19.8 (10.6, 24.9)

0.1757

1.0000

0.0649

 TEMRA

21.7 (11.6, 29.9)

18.8 (12.0, 31.9)

17.8 (12.4, 28.6)

1.0000

1.0000

1.0000

Activated T cells

 CD4+

4.8 (3.1, 7.1)

4.3 (2.3, 7.1)

3.4 (2.3, 6.0)

1.0000

0.6483

1.0000

 Th1

1.0 (0.6, 1.7)

1.2 (0.8, 1.6)

0.4 (0.2, 0.5)

0.7808

*<0.0001

*<0.0001

 Th17

0.6 (0.4, 0.7)

1.1 (0.5, 1.5)

1.1 (0.5, 1.8)

*0.0032

*0.0164

1.0000

 Treg

1.1 (1.0, 1.5)

0.9 (0.6, 1.4)

1.4 (0.7, 1.8)

0.3430

1.0000

0.2660

 Tfh

0.3 (0.2, 0.5)

0.2 (0.1, 0.5)

0.3 (0.2, 0.4)

1.0000

1.0000

0.5850

 CD8+

8.9 (5.9, 13.4)

6.8 (4.8, 13.1)

6.5 (3.8, 11.2)

0.6867

0.3812

1.0000

B cells

 Naive

61.8 (51.0, 69.4)

65.4 (58.4, 73.4)

62.0 (55.4, 68.8)

0.2550

1.0000

0.8862

 IgM memory

20.8 (10.9, 25.6)

18.1 (13.8, 22.9)

16.4 (10.3, 21.1)

0.8355

0.231

1.0000

 Class-switched

11.7 (8.9, 19.3)

10.6 (7.5, 15.7)

11.9 (8.2, 17.0)

0.8051

1.0000

1.0000

 Double negative

5.3 (4.2, 6.6)

6.1 (4.4, 10.1)

5.1 (3.8, 7.9)

0.3217

1.0000

0.7185

 Plasmocytes

2.0 (1.3, 2.9)

1.5 (0.4, 2.4)

2.5 (0.6, 4.8)

0.1329

1.0000

0.3199

Monocytes

 Classical

90.2 (82.9, 93.1)

92.3 (89.2, 94.6)

91.3 (86.1, 94.1)

0.0967

0.7704

1.0000

 Non-classical

9.5 (5.0, 15.3)

7.4 (5.3, 10.7)

6.0 (4.1, 11.6)

0.6651

0.3034

1.0000

Dendritic cells

 Myeloid

82.3 (69.6, 86.6)

74.6 (61.2, 82.5)

75.5 (67.7, 85.3)

0.3641

1.0000

1.0000

 Plasmacytoid

5.5 (3.8, 7.9)

6.9 (4.5, 11.5)

6.9 (4.9, 10.3)

0.2533

0.3666

1.0000

NK cells

 CD16+

94.7 (89.5, 97.0)

92.7 (88.9, 94.6)

91.8 (84.5, 95.0)

0.4355

0.1611

1.0000

 CD16-

4.9 (2.9, 9.1)

6.9 (4.6, 10.0)

7.9 (3.8, 12.9)

0.2301

0.3357

1.0000

  1. Data are shown by median (quartile). p values were determined by the Dunn test
  2. PAO pustulotic arthro-osteitis, PsA psoriatic arthritis, TEMRA terminally differentiated effector memory cells, Tfh follicular helper T cells
  3. *p<0.05: HC (n=30) vs PsA (n=33) vs PAO (n=22)
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Arthritis Research & Therapy

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