Fig. 6From: Augmented PFKFB3-mediated glycolysis by interferon-γ promotes inflammatory M1 polarization through the JAK2/STAT1 pathway in local vascular inflammation in Takayasu arteritisSchematic diagram showing that interferon (IFN)-γ promotes PFKFB3 expression and glycolysis, mediating M1 macrophage polarization and inflammation by JAK2/STAT1 phosphorylation, and this process could be inhibited by inhibitors tofacitinib (JAK2), fludarabine (STAT1), or PFK-015(PFKFB3)Back to article page