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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Novel alendronate-CGS21680 conjugate reduces bone resorption and induces new bone formation in post-menopausal osteoporosis and inflammatory osteolysis mouse models

Fig. 2

Characterization of osteoporotic mice show MRS7216 is effective at reversing osteoporosis. a Ovariectomy induced a significant weight increase in mice 6 weeks after the surgery. b After the treatments were administered all groups had a similar weight gain. c 6 weeks after the surgery Ovx mice had a 10% average decrease on BMD measured by DEXA scan. d Representative images of femur trabecular bone reconstruction by Ī¼CT. e Quantification of total body BMD on alendronate-PEG and MRS7216 treated mice measured by DEXA scan every 2 weeks. f,g Trabecular BMD representation of femur and L5 vertebra respectively. * p<0.05 vs Control, # p<0.05 vs Saline, & p<0.05 vs AlenP

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Arthritis Research & Therapy

ISSN: 1478-6362

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