Fig. 5

Histological studies of wear particle-induced osteolysis show a reduction in osteoclast number and an increase in osteoblast number and bone formation after MRS7216 treatment. a–d Representative images and quantification of TRAP staining of mice calvaria (in pink). b–e Representative images and quantification of ALP staining of mice calvaria (in brown). c–f Representative images and quantification of femur dynamic bone histomorphometry after double labeling with Alizarin Red and calcein. #p<0.05 vs healthy, *p<0.05 vs Saline, & p<0.05 vs AlenP