Skip to main content
Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Early removal of the infrapatellar fat pad/synovium complex beneficially alters the pathogenesis of moderate stage idiopathic knee osteoarthritis in male Dunkin Hartley guinea pigs

Fig. 3

Transcript and protein expression analyses. Normalized mRNA counts for adiponectin (A), leptin (B), FASN (C), COL2A1 (D), MMP-2 (E), NF-kB p65 (F), NF-kBp50 (G), NR4A2 (H), catalase (I), C3 (J), MCP-1 (K), and GPS2 (L) in IFP/SC and FCT of knee joints. Immunohistochemistry for MCP-1 expression in IFP/SC  (M; left hind limb) and FCT (N; right hind limb). MCP-1 is a cytokine regulated by the NF-kBp65 pathway; expression in the FCT was reduced compared to the native IFP/SC. (O) Figure representing quantitative analysis of MCP-1-stained tissue subtracted from IgG control tissue for all samples. NF-kB is a transcription factor that is known for regulating inflammatory responses within inflammatory cells; protein expression is increased in IFP/SC (P; left hind limb) versus FCT (Q; right hind limb). (R) Figure representing quantitative analysis of p65 stained tissue subtracted from IgG control tissue for all samples. P-values were determined by paired t-test† for non-parametric Wilcoxon test× for non-normally distributed data. ***P <0.0005, **P<0.005, and *P<0.05

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us