Fig. 4

Clinical and quantitative MicroCT. Representative photos from microCT evaluation of knee joints using the published scoring system. (A) Coronal and sagittal (B) sections of an IFP/SC-containing knee. Subchondral bone sclerosis is present on the medial femoral condyle (coronal section, red arrow). An osteophyte is highlighted on the proximal patella (sagittal section, yellow arrow). (C) Coronal and sagittal sections of the FCT limb, which is relatively unaffected. (E) The clinical microCT OA score demonstrated a significant decrease in bony changes in the FCT knees (P= 0.0020). Contributions to whole joint microCT OA score components included location of osteophytes (F), size of osteophytes (G), and subchondral bone sclerosis (H). Cross-section of tibiae containing either IFP/SC (I) or FCT (J); osteophytes are highlighted on the medial posterior tibia (red dashed circles). (K) Osteophyte volume mm³ was significantly decreased in FCT versus IFP/SC knees. Trabecular vBMD (g/cm³) of the medial femora (L) and tibiae (M) were decreased by the FCT when compared to the IFP/SC. Normally distributed data with similar variance were compared using parametric t test^†. Data with non-Gaussian distribution were compared using non-parametric Wilcoxon^× matched – pairs signed rank test. **P<0.005 and *P<0.05