Fig. 2

Naringenin decreased the expression of cFos in the spinal cord dorsal horn in CIA rats. A Representative micrographs of the expression of cFos in the spinal cord dorsal horn on days 28 (PID 21) and 42 (PID 35). B, C Expression of cFos in the spinal cord dorsal horn in CIA and NAR groups on the day 28 (PID 21) and day 42 (PID 35). *P < 0.05 vs. naive group, ** P < 0.01 vs. naive group, ^#P < 0.05 vs. CIA model group, by repeated-measures one-way ANOVA followed by post hoc Dunnett’s multiple comparisons test. The dotted white lines lineate the edge of the section. The second column is a higher magnification of the white box indicated in the first column images. All scale bars are 50 μm. The relative mean fluorescence intensity of cFos were quantified using the Image J software. The data are presented as means ± SEM (n = 5 rats per group)