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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: TRPA1 as a potential factor and drug target in scleroderma: dermal fibrosis and alternative macrophage activation are attenuated in TRPA1-deficient mice in bleomycin-induced experimental model of scleroderma

Fig. 1

TRPA1-deficient mice presented attenuated dermal thickening in response to bleomycin injections. Skin sections of control and bleomycin treated wild type (WT) and TRPA1-deficient (TRPA1−/−) mice were stained with hematoxylin and eosin. Representative images are shown (A) and data of dermal thickness measurements are summarized as a graph (B). Dermal thickness (rectangular blank bar in A) was calculated by averaging the thickness measured at six randomly selected locations in each section using the ImageJ software. Bars represent means of the dermal thickness + SEM; n  =  6. ***p < 0.001 between bleomycin-treated WT and TRPA1-deficient mice; ###p < 0.001 between control and bleomycin-treated mice within the same genotype

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Arthritis Research & Therapy

ISSN: 1478-6362

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