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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cells

Fig. 3

Serum TGF-β-LAP, LIF and VEGF-A levels are elevated in individuals with hyperuricemia and TGF-β-LAP correlates positively to serum urate. Serum proteins were analysed by Olink proteomics panel. Flaring gout patients (n = 36) are marked in red dots. NPX was shown for TGF-β-LAP (A), LIF (B) and VEGF-A (C). Means were compared by Welch ANOVA with Games-Howell’s multiple comparisons test. *p < 0.05, **p < 0.01, ***p < 0.001. Spearman correlation was used to analyse the correlation between serum TGF-β-LAP to urate levels (D). Serum LIF levels were significantly higher in flaring gout patients compared to intercritical gout patients (Welch’s t-test p < 0.0001)

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Arthritis Research & Therapy

ISSN: 1478-6362

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