Fig. 5From: Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritisSurvival rate of anti-rheumatic drugs between RA patients with and without anti-cit-OPN antibodies. A Positivity of anti-cit-OPN antibody from RA sera collected over 3 consecutive years, measured by ELISA. B Relationship between serum anti-CCP antibody and anti-cit-OPN antibody using stored serum in the 2016 cohort. C Survival rate of TNF inhibitors due to lack of efficacy between RA patients with and without anti-cit-OPN antibodies in the 2016 cohort. Patients in whom TNF inhibitors were discontinued within 90Â days were excluded. D Survival rate of CTLA4-Ig due to lack of efficacy between RA patients with and without anti-cit-OPN antibodies. Patients in whom the drug was discontinued within 90Â days were excludedBack to article page