Fig. 5From: MYC promotes fibroblast osteogenesis by regulating ALP and BMP2 to participate in ectopic ossification of ankylosing spondylitisPossible role of MYC in fibroblasts during ectopic ossification in AS. IFN-γ may upregulate the expression of MYC in fibroblasts, and MYC further binds the promoters of ALP and BMP2 to induce their expression, resulting in fibroblast transdifferentiation to osteoblasts and ligament ossificationBack to article page