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Table 1 Participants’ characteristics

From: Factors associated with the composition of the gut microbiome in patients with established rheumatoid arthritis and its value for predicting treatment responses

 

RA (n = 94)

Healthy control (n = 30)

P

Age, years

57.4 ± 10.2

47.9 ± 3.5

 < 0.001

Female, n (%)

87 (92.6)

30 (100)

0.194

BMI, kg/m2

22.7 ± 2.7

23.9 ± 3.0

0.064

Smoking, n (%)

2 (2.1)

3 (10.0)

0.091

Disease duration, years

8.7 ± 7.9

-

-

ACPA-positive, n (%)

75/89† (84.3)

-

-

RF-positive, n (%)

71/93† (76.3)

-

-

Medications

csDMARDs, n (%)

   

 Methotrexate

53 (56.4)

-

 

 Leflunomide

39 (41.5)

-

 

 Sulfasalazine

14 (14.9)

-

 

 Hydroxychloroquine

39 (41.5)

-

 

 csDMARD combination

29 (30.9)

  

Biological DMARDs, n (%)

39 (41.5)

-

 

Oral glucocorticoids, n (%)

64 (68.1)

-

 

NSAIDs, n (%)

51 (54.3)

  

Disease activity

   

DAS28

3.0 ± 1.5

  

Remission (DAS28 < 2.6), n (%)

46 (48.9)

  

Low disease activity (2.6 ≤ DAS28 ≤ 3.2), n (%)

7 (7.5)

  

Moderate disease activity (3.2 < DAS28 ≤ 5.1), n (%)

31 (33.0)

  

High disease activity (DAS28 > 5.1), n (%)

10 (10.6)

  
  1. †Among all RA participants, information about ACPA and RF was available for 89 and 93 patients, respectively
  2. ACPA, Anti-citrullinated protein antibody; BMI, body mass index; csDMARDs, conventional synthetic disease-modifying anti-rheumatic drugs; DAS28, Disease Activity Score in 28 Joints; NSAID, non-steroidal anti-inflammatory drugs; RF, rheumatoid factor