Skip to main content
Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: TAK-715 alleviated IL-1β-induced apoptosis and ECM degradation in nucleus pulposus cells and attenuated intervertebral disc degeneration ex vivo and in vivo

Fig. 4

TAK-715 reduced IL-1β-induced apoptosis in NPCs. NPCs were preincubated with TAK-715 for 2 h, and then, IL-1β was added for 48 h. A Western blot analysis was used to analyze Bcl-2, Bax, and cleaved caspase-3 in NPCs; B-D Immunoblots of Bcl-2, Bax, and cleaved caspase-3 were quantitatively analyzed. E Flow cytometric measurement of the apoptosis incidence in NPCs. E The apoptosis rate was quantitatively analyzed. The data are presented as the mean ± SD (*P < 0.05; **P < 0.01; ***P < 0.001)

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us