Re-thinking osteoarthritis pathogenesis: what can we learn (and what do we need to unlearn) from mouse models about the mechanisms involved in disease development

Table 1 Summary of commonly used murine models of OA

	Alignment with risk factors for OA in humans
Spontaneously occurring OA
E.g. aged C57Bl/6	Age
STR/ort mouse	Metabolic syndrome, high body weight
Injury-induced OA
Surgically induced
Destabilised medial meniscus (DMM)	Post-traumatic OA (PTOA)
Anterior cruciate ligament transection (ACLT)	Post-traumatic OA (PTOA)
Other damage-induced
Collagenase induced	Cartilage degradation
Monosodium iodoacetate (MIA), papain	Joint inflammation

ISSN: 1478-6362