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Table 2 Observed patient-reported outcomes at baseline and at 36 months

From: Improvement in patient-reported outcomes and work productivity following 3-year ustekinumab or tumour necrosis factor inhibitor treatment in patients with psoriatic arthritis: results from the PsABio real-world study

Patient-reported outcomes

UST (n=219)

Mean [95%CI]

TNFi (n=218)

Mean [95%CI]

EQ-5D health state: VAS scorea

 Baseline

55.2 [52.3; 58.0]

51.1 [48.2; 54.0]

 36 months

66.2 [62.4; 69.9]

70.0 [66.0; 74.1]

 Change from baseline

11.0 [6.5; 15.4]

18.9 [14.0; 23.9]

PsAID-12: overall PsAIDb

 Baseline

5.4 [5.1; 5.7]

5.3 [5.0; 5.6]

36 months

2.5 [2.2; 2.8]

1.8 [1.5; 2.0]

 Change from baseline

−2.9 [−3.2; −2.5]

−3.5 [−3.9; −3.2]

PsAID-12: painc

 Baseline

6.0 [5.6; 6.3]

6.1 [5.7; 6.4]

36 months

3.0 [2.7; 3.4]

2.3 [2.0; 2.6]

Change from baseline

2.9 [3.3;2.5]

3.8 [4.2;3.4]

PsAID-12: skind

 Baseline

6.0 [5.6; 6.4]

4.8 [4.4; 5.2]

 36 months

2.1 [1.8; 2.4]

1.6 [1.3; 1.9]

 Change from baseline

−3.9 [−4.4; −3.4]

−3.1 [−3.6; −2.7]

WPAI: work time missed (absenteeism)e, %

 Baseline

13.2 [6.8; 19.7]

24.0 [16.4; 31.6]

 36 months

1.5 [−0.1; 3.0]

3.2 [0.6; 5.8]

 Change from baseline

−11.8 [−18.4; −5.1]

−20.8 [−27.9; −13.6]

WPAI: impairment while working (presenteeism)f, %

Baseline

37.8 [31.9; 43.7]

51.0 [45.4; 56.6]

 36 months

16.3 [12.2; 20.3]

13.7 [10.1; 17.2]

Change from baseline

21.6 [28.3;14.8]

37.3 [42.8;31.8]

WPAI: work productivity lossg, %

Baseline

43.3 [35.6; 51.1]

58.8 [52.4; 65.2]

 36 months

18.4 [13.5; 23.3]

14.3 [10.3; 18.3]

Change from baseline

24.9 [34.0;15.8]

44.5 [50.6;38.4]

WPAI: activity impairmenth, %

 Baseline

53.1 [49.2; 57.0]

57.9 [54.2; 61.6]

36 months

25.1 [21.6; 28.6]

17.3 [14.4; 20.1]

Change from baseline

28.0 [32.4;23.5]

40.7 [44.5;36.8]

  1. Results reflect the latest assessments for patients considered as remaining on their initial treatment through 3 years. Bold text indicates non-overlapping 95% CI. Baseline, 36-month and change from baseline values are unadjusted data with LOCF imputation. Only skin and pain domains of PsAID-12 are presented here
  2. a26 patients from the UST group are missing, and 27 patients from the TNFi group are missing
  3. b7 patients from the UST group are missing, and 23 patients from the TNFi group are missing
  4. c7 patients from the UST group are missing, and 22 patients from the TNFi group are missing
  5. d5 patients from the UST group are missing, and 21 patients from the TNFi group are missing
  6. e143 patients from the UST group are missing, and 128 patients from the TNFi group are missing
  7. f123 patients from the UST group are missing, and 117 patients from the TNFi group are missing
  8. g143 patients from the UST group are missing, and 133 patients from the TNFi group are missing
  9. h15 patients from the UST group are missing, and 21 patients from the TNFi group are missing
  10. CI, confidence interval; EQ-5D health state VAS, EQ-5D-3L health visual analogue scale, LOCF Last observation carried forward, PsAID-12 The 12-item Psoriatic Arthritis Impact of Disease questionnaire, TNFi Tumour necrosis factor inhibitor, UST Ustekinumab, VAS Visual analogue scale, WPAI Work Productivity and Activity Impairment