Fig. 6

Transcription factors (TFs) predicted to bind within the DMR. A Section 1,  location of the 8 DMR CpGs; cg18131582 is CpG9 (red line). Also shown are the locations of the DNA variants (blue bars) rs943409 (G > A) and rs734657 (C > A). Section 2, TF-binding sites as predicted by JASPAR and visualised in the UCSC Genome Browser (hg19). The TFs are marked by grey bars with the direction of the arrows within the boxes indicating the DNA strand the TF is predicted to bind to (arrows pointing to the left = antisense strand,  arrows pointing to the right = sense strand). B, C Expression levels (transcripts per million (TPM)) of the TFs in synovium synovial fibroblasts from OA patients (n = 10) and in cartilage chondrocytes from OA patients (n = 10). Bars show the mean ± SEM. The y-axes are linear segmented scales with 3 segments