Table 1 Clinical and structural parameters
Before induction day | Post-induction day | |||
|---|---|---|---|---|
D0 | D4 (preclinical) | D11 (onset) | D28 (acute) | |
Body weight (g) | ||||
Controls | 178 ± 7 | 208 ± 14 | 248 ± 3 | 309 ± 3 |
AIA | 189 ± 4 | 192 ± 5* | 216 ± 4*** | 207 ± 3*** |
Paw diameter (mm) | ||||
Controls | 6.8 ± 0.1 | 7.1 ± 0.1 | 7.2 ± 0.1 | 7.2 ± 0.1 |
AIA | 6.3 ± 0.4 | 6.9 ± 0.1 | 7.9 ± 0.2** | 9.4 ± 0.3*** |
Arthritis score | ||||
Controls | 0 | 0 | 0 | 0 |
AIA | 0 | 0 | 1.9 ± 0.9 | 3.9 ± 1.0 |
Radiographic score | ||||
Controls | 0 | 0.3 ± 0.5 | 0.3 ± 0.5 | 0.07 ± 0,3 |
AIA | 0 | 0.3 ± 0.5 | 4.1 ± 1.7*** | 23.8 ± 8.1*** |