Table 7 Risk factors associated with a first serious adverse event during rituximab treatment

Age at first  RTX

  < 40 years

Reference

Reference

 40 to 60 years

1.06

0.42, 2.68

1.04

0.41, 2.69

  > 60 years

3.86

1.65, 9.03

3.21

1.29, 7.95

Charlson comorbidity index

 0

Reference

Reference

 1

0.64

0.28, 1.47

0.66

0.28, 1.59

 2

0.68

0.24, 1.87

0.72

0.25, 2.05

  ≥ 3

2.60

1.12, 6.02

1.93

0.79, 4.68

Anti-drug antibodies identification

2.73

1.12, 6.61

3.05

1.01, 9.18

Previous treatment with MTX

0.49

0.30, 0.79

0.47

0.24, 0.90

B cells depletion (≤ 5 cell/mm³)

0.31

0.12, 0.78

0.27

0.09, 0.82