Table 8 Risk factors associated with a first serious infectious adverse event during rituximab treatment

Gender: male

2.03

1.02, 4.07

1.52

0.71, 3.26

Age at first  RTX

  < 40 years

Reference

Reference

 40 to 60 years

1.36

0.38, 4.87

1.16

0.32, 4.26

  > 60 years

3.02

0.90, 10.1

1.84

0.51, 6.60

Charlson comorbidity index

 0

Reference

Reference

 1

0.33

0.13, 0.87

0.38

0.13, 1.06

 2

0.41

0.11, 1.45

0.42

0.11, 1.57

  ≥ 3

1.71

0.65, 4.52

1.21

0.41, 3.59

Concurrent use of glucocorticoids

0.99

0.49, 1.99

1.06

0.48, 2.33

Hypogammaglobulinaemia

 None

Reference

Reference

 Mild (5–6.9 g/l)

1.29

0.53, 3.11

1.44

0.55, 3.76

 Moderate to severe (< 5 g/l)

3.13

1.47, 6.70

2.54

1.03, 6.28

RTX indication

 RA

Reference

Reference

 CTD

0.49

0.20, 1.20

0.87

0.32, 2.35

 Vasculitis

2.76

1.09, 6.99

1.79

0.62, 5.14