Fig. 2

Adjusted odds ratios of single-trait and MTAG-based PRSs of traits with correlations with knee OA. Adjusted odds ratios per standard deviation and 95% confidence intervals of the risk of knee OA were calculated using a logistic regression model, including age, sex, 10 principal components, and a dummy variable for the array type used in genotyping as covariates. PRS, polygenic risk score; MTAG, multi-trait analysis of genome-wide association; OA, osteoarthritis; GWAS, genome-wide association study; TKR, total knee replacement; TJR, total knee and/or hip joint replacement; BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; UKB, UK Biobank; CI, confidence interval