Fig. 1

The glycopatterns exhibited significant differences between normal and OA cartilage. a Representative H&E staining images of OA and normal articular cartilages. The articular cartilage sections from OA patients displayed typical characteristics of OA compared with normal cartilage. Scale bar = 100 μm. b The representative scanned images of OA and normal cartilage. The lectins with increased or decreased NFIs in OA cartilage are marked with red or white boxes respectively. c The NIFs of 7 lectins showed significantly altered in OA (n = 13) to control (n = 11) cartilage based upon foldchange and p value. The data were represented as Mean with SEM. d Hierarchical clustering analysis of the 37 lectins with OA and control groups. Glycan profiles of normal and OA cartilage were clustered (average linkage, correlation similarity). Samples are listed in rows and the lectins are listed in columns. The color and intensity of each square indicated relative fluorescence intensities of lectins in the row. Red, high; blue, low; white, medium. e Principal component analysis of the difference between normal and OA cartilages. The NFIs of 7 lectins from OA and control groups were subjected to principal component analysis, normal and OA samples were indicated by cyan triangle and red dot, respectively