Characterization of aberrant glycosylation associated with osteoarthritis based on integrated glycomics methods

Table 1 Heterogeneities of specific glycosylation sites of glycoproteins in OA cartilage

UniPort Acc	Protein name	Annotated sequence	Glycan composition	Foldchange (OA/N)	p value
P02751	Fibronectin (FN1)	DQCIVDDITYNVN⁵²⁸DTFHK	N4H5S2	0.01	< 0.0001
P02751	Fibronectin (FN1)	DQCIVDDITYNVN⁵²⁸DTFHK	N4H4F1S1	100	< 0.0001
P16112	Aggrecan core protein (ACAN)	TVYVHAN³³³QTGYPDPSSR	N5H8F1	0.01	< 0.0001
			N6H4S1	100	< 0.0001
			N4H3F1	100	< 0.0001
			N5H3F1	100	< 0.0001
			N2H5	100	< 0.0001
			N6H4	100	< 0.0001
		TVYLYPN⁶⁵⁸QTGLPDPLSR	N5H4F1S2	0.01	< 0.0001
			N6H6F1	0.01	< 0.0001
			N6H7	0.01	< 0.0001
			N7H6	0.01	< 0.0001
			N2H11	5.98	0.046

ISSN: 1478-6362