Deconvolution of whole blood transcriptomics identifies changes in immune cell composition in patients with systemic lupus erythematosus (SLE) treated with mycophenolate mofetil

Table 3 Ordered logistic regression models of the association between MMF exposure and quartiles of peripheral blood immune cell frequency

Cell type (quartiles)	Unadjusted			Model 1^a			Model 2^b
Cell type (quartiles)	OR	95% CI	p	OR	95% CI	p	OR	95% CI	p
Resting macrophages	0.354	0.176, 0.771	0.004	0.386	0.178, 0.840	0.016	0.329	0.177, 0.872	0.022
Naïve CD4 + T cells	0.390	0.195, 0.776	0.007	0.398	0.184, 0.859	0.019	0.369	0.167, 0.816	0.014
Regulatory T cells	0.363	0.181, 0.728	0.004	0.227	0.099, 0.521	< 0.001	0.216	0.092, 0.508	< 0.001
Activated CD4 + memory T cells	1.952	0.984, 3.869	0.055	2.174	1.014, 1.659	0.046	2.447	1.120, 5.346	< 0.001
Monocytes	0.528	0.266, 1.045	0.067	0.527	0.244, 1.139	0.103	0.579	0.262, 1.279	0.176

^aModel 1: adjusted for age, gender, ethnicity, and disease duration
^bModel 2: as for model 1 plus presence of renal disease (BILAG A/B) and corticosteroid use (Y/N)

ISSN: 1478-6362