Fig. 2

Drp1 induces gouty arthritis via NF-κB pathway and NLRP3 inflammasome activation. A The protein levels of Drp1 and key molecules of NF-κB/NLRP3 signaling were detected by western blot. B, The protein levels of key molecules of NF-κB/NLRP3 signaling were detected by western blot. C The secretion of IL-1β, TNF-α and IL-6 were measured by ELISA assay. D The activities of antioxidant enzymes were detected using commercial kits. E The LDH release was measured using commercial kit. *, P < 0.05, **, P < 0.01, ***, P < 0.001