Table 1 The conventional classification of CCLs and their affinity receptors
From: CC chemokines and receptors in osteoarthritis: new insights and potential targets
Chemokine (other name) | Receptor |
|---|---|
Inflammatory | |
 CCL2 (MCP-1) | CCR2 |
 CCL3 (MIP-1α) | CCR1, CCR5 |
 CCL5 (RANTES) | CCR1, CCR3, CCR5 |
 CCL7 (MCP-3) | CCR1, CCR2, CCR3 |
 CCL8 (MCP-2) | CCR1, CCR2, CCR5 |
 CCL11 (Eotaxin-1) | CCR3, CCR5 |
 CCL13 (MCP-4) | CCR2, CCR3 |
 CCL14 (HCC-1) | CCR1, CCR3, CCR5 |
 CCL15 (HCC-2) | CCR1, CCR3 |
 CCL24 (Eotaxin-2) | CCR3 |
 CCL26 (Eotaxin-3) | CCR3 |
 CCL27 (CTACK) | CCR10 |
 CCL28 (MEC) | CCR3, CCR10 |
Homeostatic | |
 CCL18 (DC-DK1) | PITPNM3 |
 CCL19 (ELC) | CCR7 |
 CCL21 (SLC) | CCR7 |
Dual-Function | |
 CCL1 (I-309) | CCR8 |
 CCL17 (TARC) | CCR4 |
 CCL20 (LARC) | CCR6 |
 CCL22 (MDC) | CCR4 |
 CCL25 (TECK) | CCR9 |