Patients with SPARCC > 0 (N = 545) | ||||||
---|---|---|---|---|---|---|
Locationa | Severityb | |||||
Upper sites only N = 64 | Lower sites only N = 139 | Upper and lower sites N = 342 | 1–2 sites N = 145 | > 2– ≤ 5 sites N = 152 | > 5 sites N = 242 | |
Tofacitinib 5 mg BID | N = 18 | N = 53 | N = 106 | N = 47 | N = 58 | N = 71 |
Tofacitinib 10 mg BID | N = 23 | N = 45 | N = 123 | N = 45 | N = 48 | N = 95 |
Placebo | N = 23 | N = 41 | N = 113 | N = 53 | N = 46 | N = 76 |
Female, n (%) | 7 (38.9) | 17 (32.1) | 64 (59.4) | 19 (40.4) | 24 (41.4) | 43 (60.6) |
9 (39.1) | 19 (42.2) | 83 (67.5) | 18 (40.0) | 24 (50.0) | 67 (70.5) | |
7 (30.4) | 19 (46.3) | 76 (67.3) | 22 (41.5) | 25 (54.3) | 54 (71.1) | |
Age, years, mean (SD) | 53.3 (12.5) | 43.9 (13.5) | 50.8 (11.5) | 45.4 (14.1) | 49.1 (11.5) | 51.3 (12.2) |
43.3 (14.3) | 48.9 (13.0) | 51.3 (10.5) | 47.8 (12.9) | 46.6 (13.2) | 52.0 (10.1) | |
48.8 (12.7) | 47.8 (13.8) | 49.1 (12.7) | 47.4 (12.8) | 48.7 (14.7) | 49.8 (11.9) | |
Race, White, n (%) | 17 (94.4) | 51 (96.2) | 100 (94.3) | 46 (97.9) | 54 (93.1) | 67 (94.4) |
22 (95.7) | 41 (91.1) | 115 (93.5) | 39 (86.7) | 43 (89.6) | 93 (97.9) | |
23 (100) | 41 (100) | 103 (91.2) | 52 (98.1) | 44 (95.7) | 69 (90.8) | |
BMI, kg/m2, mean (SD) | 29.0 (7.2) | 29.0 (5.9) | 30.7 (6.6) | 29.1 (7.1) | 31.0 (7.0) | 29.7 (5.5) |
27.7 (4.7) | 28.9 (5.8) | 30.8 (6.4) | 28.3 (5.1) | 29.3 (5.6) | 31.0 (6.7) | |
29.4 (5.9) | 29.8 (4.6) | 29.4 (6.0) | 29.0 (4.9) | 29.3 (6.2) | 30.1 (5.9) | |
PsA duration, years, mean (SD) | 9.2 (8.6) | 6.9 (6.3) | 8.6 (7.7) | 7.8 (7.7) | 8.0 (6.8) | 8.6 (7.8) |
8.6 (8.5) | 8.3 (7.6) | 7.4 (6.2) | 8.0 (8.3) | 6.9 (6.4) | 8.0 (6.3) | |
5.5 (4.6) | 10.0 (9.2) | 7.7 (6.2) | 10.1 (8.8) | 6.6 (4.6) | 7.4 (6.3) | |
CRP, mg/L, mean (SD) | 17.6 (32.7) | 19.7 (29.6) | 10.4 (15.4) | 16.8 (23.9) | 15.3 (27.6) | 11.0 (17.5) |
8.6 (8.4) | 19.5 (32.1) | 11.1 (20.7) | 12.4 (18.0) | 15.3 (27.5) | 11.9 (23.5) | |
13.2 (33.6) | 9.7 (10.2) | 12.0 (20.8) | 11.9 (23.5) | 11.4 (20.8) | 11.7 (19.8) | |
LEI, mean (SD) [N1]c | 1.5 (0.7) [12] | 2.1 (1.1) [35] | 3.2 (1.6) [101] | 1.3 (0.5) [26] | 2.2 (1.0) [50] | 3.9 (1.4) |
1.7 (1.1) [15] | 1.9 (1.1) [31] | 3.8 (1.6) [113] | 1.2 (0.4) [24] | 2.5 (1.2) [40] | 4.1 (1.5) [93] | |
1.6 (0.8) [18] | 1.8 (0.9) [24] | 3.2 (1.5) [107] | 1.4 (0.6) [34] | 2.2 (1.0) [42] | 3.7 (1.4) [73] | |
SPARCC, mean (SD) | 2.3 (1.5) | 3.0 (1.9) | 7.2 (3.7) | 1.6 (0.5) | 4.0 (0.8) | 9.1 (3.1) |
1.7 (1.2) | 3.1 (2.4) | 8.1 (3.7) | 1.3 (0.5) | 3.9 (0.7) | 9.4 (3.2) | |
2.0 (1.2) | 2.4 (1.4) | 7.1 (3.4) | 1.6 (0.5) | 4.0 (0.8) | 8.8 (2.8) | |
Dactylitis presence, DSS > 0, n (%) | 9 (50) | 33 (62.3) | 60 (56.6) | 24 (51.1) | 33 (56.9) | 45 (63.4) |
12 (52.2) | 30 (66.7) | 65 (52.8) | 25 (55.6) | 27 (56.3) | 53 (55.8) | |
10 (43.5) | 23 (56.1) | 61 (54.0) | 25 (47.2) | 24 (52.2) | 44 (57.9) | |
TJC68, mean (SD) [N1]d | 13.7 (8.4) [6] | 18.2 (9.4) [25] | 25.2 (14.6) [50] | 17.1 (10.3) [21] | 20.8 (11.1) [31] | 27.9 (16.0) [28] |
15.6 (6.9) [13] | 18.3 (15.0) [19] | 25.8 (13.2) [50] | 15.1 (8.6) [26] | 16.7 (12.6) [21] | 31.8 (12.0) [33] | |
21.1 (15.7) [13] | 15.0 (5.3) [20] | 28.3 (15.9) [46] | 15.3 (8.7) [26] | 23.1 (13.5) [16] | 31.0 (16.0) [35] | |
SJC66, mean (SD) [N1]d | 6.7 (3.6) [6] | 12.4 (5.7) [25] | 14.6 (11.3) [50] | 11.6 (8.4) [21] | 12.9 (7.4) [31] | 15.4 (12.4) [28] |
10.5 (3.9) [13] | 12.0 (8.6) [19] | 13.2 (8.9) [50] | 10.7 (6.2) [26] | 9.4 (6.2) [21] | 15.6 (9.8) [33] | |
12.8 (11.3) [13] | 9.4 (5.6) [20] | 13.7 (10.2) [46] | 10.0 (6.9) [26] | 13.6 (10.0) [16] | 14.1 (10.9) [35] | |
PASDAS, mean (SD) [N1]d | 5.9 (1.4) | 6.2 (1.2) [52] | 6.4 (1.1) [102] | 6.1 (1.3) [35] | 6.3 (1.2) [45] | 6.7 (1.0) [52] |
6.1 (0.9) | 6.4 (1.0) | 6.6 (1.1) [119] | 6.1 (0.9) [35] | 6.6 (1.1) [36] | 6.9 (1.2) [65] | |
5.6 (1.2) [22] | 6.0 (1.2) [40] | 6.4 (1.1) [112] | 5.9 (1.1) [39] | 6.6 (1.0) [30] | 6.8 (0.9) [56] | |
DAPSA, mean (SD) [N1]d | 44.5 (25.3) | 42.2 (16.4) | 52.4 (23.9) [105] | 43.1 (22.6) [35] | 45.2 (18.2) [45] | 59.8 (25.8) [54] |
35.1 (12.9) | 44.5 (23.9) | 57.9 (25.8) | 37.2 (14.7) [35] | 46.5 (24.7) [36] | 66.1 (27.1) [66] | |
38.4 (22.7) | 36.0 (12.5) | 51.7 (24.4) | 37.1 (16.3) [39] | 45.8 (20.0) [30] | 60.2 (25.2) [56] | |
CPDAI, mean (SD) [N1]e | 8.9 (1.8) [13] | 10.6 (2.3) [40] | 11.3 (2.0) [62] | 9.7 (2.2) [32] | 10.4 (2.0) [28] | 12.2 (1.9) [41] |
9.6 (2.5) [15] | 11.0 (2.4) [30] | 11.3 (2.3) [71] | 9.6 (2.3) [17] | 11.6 (1.9) [30] | 12.1 (2.3) [45] | |
9.1 (2.3) [16] | 10.5 (2.4) [33] | 10.8 (2.5) [74] | 10.1 (2.3) [31] | 11.0 (2.4) [26] | 11.9 (1.9) [39] | |
FACIT-F total score, mean (SD) [N1]d | 25.7 (14.0) | 25.2 (11.1) | 25.2 (11.1) [105] | 26.2 (11.9) | 25.8 (11.6) | 24.1 (10.9) [70] |
31.2 (10.0) | 25.6 (9.3) | 25.0 (10.4) | 29.8 (10.3) | 24.9 (9.4) | 24.4 (10.2) | |
31.7 (11.5) | 25.0 (9.7) | 27.3 (10.4) | 28.3 (10.5) | 29.0 (11.5) | 25.8 (9.8) | |
Arthritis pain (VAS), mean (SD) [N1]d | 62.8 (24.0) | 59.0 (22.2) | 56.0 (22.6) [105] | 60.3 (25.3) | 54.3 (22.5) | 58.4 (20.9) [70] |
54.5 (23.3) | 58.6 (22.8) | 60.4 (20.7) | 57.6 (21.6) | 56.8 (22.8) | 61.1 (21.0) | |
44.2 (21.2) | 55.2 (23.7) | 57.3 (24.3) | 48.7 (23.0) | 58.1 (25.6) | 58.3 (22.6) |