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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Iguratimod suppresses Tfh cell differentiation in primary Sjögren’s syndrome patients through inhibiting Akt/mTOR/STAT3 signaling

Fig. 3

Transcriptome analysis of IGU-treated CD4+ T cells. A Volcano plot of DEGs between IGU-treated (n = 3) and untreated (n = 3) naïve CD4+ T cells under Tfh condition (red, upregulated, n = 126; green, downregulated, n = 275). B Heatmap of top 200 DEGs (up = 100, down = 100). C KEGG pathway enrichment analysis of DEGs. D Overlapping between KEGG pathway enrichment analysis and target prediction of IGU. E Venn diagram of predicted IGU targets and PI3K-Akt pathway. F Molecular docking diagram of binding sites of IGU on PDK1

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Arthritis Research & Therapy

ISSN: 1478-6362

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