Table 1 Estimates of the linear mixed-effects models for the course of body weight, ankle size, and clinical arthritis score

Intercept

3.03

0.05

 < 0.001

0.26

0.42

0.54

28.29

0.48

 < 0.001

Day

0.30

0.02

 < 0.001

0.89

0.27

0.001

3.78

0.12

 < 0.001

Day²

0.19

0.02

 < 0.001

 − 0.87

0.25

0.001

4.85

0.11

 < 0.001

Day³

0.33

0.04

 < 0.001

 − 0.33

0.48

0.48

7.91

0.22

 < 0.001

Day⁴

0.21

0.02

 < 0.001

 − 0.75

0.23

0.001

4.82

0.11

 < 0.001

Genotype tg

 − 0.04

0.06

0.49

 − 0.24

0.47

0.61

 − 3.08

0.54

 < 0.001

Genotype tg * day

0.02

0.02

0.32

 − 0.68

0.27

0.012

1.53

0.12

 < 0.001

Genotype tg * day²

 − 0.01

0.02

0.71

0.19

0.27

0.48

1.42

0.12

 < 0.001

Genotype tg * day³

 − 0.08

0.04

0.06

 − 0.62

0.52

0.23

2.67

0.24

 < 0.001

Genotype tg * day⁴

0.02

0.02

0.29

0.56

0.24

0.023

1.56

0.11

 < 0.001

STIA

0.07

0.06

0.24

2.48

0.49

 < 0.001

 − 0.32

0.55

0.57

STIA * day

0.19

0.02

 < 0.001

2.76

0.28

 < 0.001

 − 0.12

0.13

0.33

STIA * day²

0.06

0.02

0.009

 − 0.10

0.27

0.72

0.01

0.12

0.96

STIA * day³

0.51

0.04

 < 0.001

5.81

0.54

 < 0.001

 − 0.39

0.24

0.11

STIA * day⁴

 − 0.18

0.02

 < 0.001

 − 2.72

0.25

 < 0.001

0.59

0.11

 < 0.001

Boost day 14

 − 0.10

0.01

 < 0.001

0.09

0.12

0.44

 − 0.49

0.06

 < 0.001

Boost day 28

0.03

0.01

0.004

1.50

0.12

 < 0.001

 − 0.42

0.06

 < 0.001