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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Causal relationship between PCSK9 inhibitor and autoimmune diseases: a drug target Mendelian randomization study

Fig. 4

Sensitivity analysis of HMGCR on coronary heart disease and autoimmune diseases. Leave-one-out analysis of HMGCR on A CHD, B SLE, C MG, D RA, E asthma, F CD, G UC, and H T1D. The leave-one-out method is used to evaluate the excessive impact of a single SNP on MR analysis if the comprehensive effect of the remaining SNPs is consistent with the main effect after removing one SNP. SNP, single nucleotide polymorphisms; HMGCR, 3-hydroxy-3-methylglutaryl-coenzyme A reductase; CHD, coronary heart disease; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; MG, myasthenia gravis; CD, Crohn’s disease; UC, ulcerative colitis; T1D, type 1 diabetes

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Arthritis Research & Therapy

ISSN: 1478-6362

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