Fig. 4

Tau deletion decreases the inflammation of ankle joints in CIA mice. A-C Representative images of H&E (A), Safranin O (B), and TRAP staining (C) in ankle joints from WT and Tau-/- mice with or without CIA. Scale bar: 100 µm. D, E Inflammation score (D) and cartilage damage score (E) were evaluated according to the scoring system. F Histomorphometric analysis of osteoclast surface per bone surface (Oc.S/BS). G, H Serum levels of IL-1β (G) and IL-6 (H) were measured by ELISA. n = 6 mice for each group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001