Table 2 The HR (95% CIs) for all-cause and cardiovascular mortality according to serum Klotho concentration

All-cause mortality

 Number of deaths (%)

55 (26.07%)

29 (13.88%)

31 (14.76%)

29 (13.74%)

 Model 1: HR (95% CI),

P value

Ref

0.51 (0.26, 0.99)

0.049

0.45 (0.24, 0.81)

0.008

0.39 (0.22, 0.67)

0.001

 Model 2: HR (95% CI),

P value

Ref

0.49 (0.25, 0.97)

0.040

0.43 (0.23, 0.79)

0.007

0.43 (0.23, 0.70) 0.001

 Model 3: HR (95% CI),

P value

Ref

0.49 (0.25, 0.96)

0.038

0.44 (0.24, 0.81)

0.008

0.41 (0.24, 0.71) 0.001

Cardiovascular mortality

 Number of deaths

18 (8.53%)

4 (1.91%)

6 (2.86%)

7 (3.32%)

 Model 1: HR (95% CI),

P value

Ref

0.21 (0.06, 0.76)

0.010

0.32 (0.08, 1.23)

0.100

0.30 (0.10, 0.88)

0.030

 Model 2: HR (95% CI),

P value

Ref

0.18 (0.06, 0.58)

0.004

0.26 (0.07, 0.93)

0.039

0.30 (0.12, 0.76)

0.012

 Model 3: HR (95% CI),

P value

Ref

0.12 (0.04, 0.38)

0.001

0.27 (0.08, 0.91)

0.035

0.24 (0.10, 0.54)

0.001