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Table 3 Prognostic factors associated with SLE-PAH patients (Cox proportional hazards model)

From: Clinical characteristics and prognosis in systemic lupus erythematosus-associated pulmonary arterial hypertension based on consensus clustering and risk prediction model

Factors

Univariate

Multivariate

HR

95% CI

P-value*

HR

95% CI

P-value*

Age at diagnosis (≥ 38 years)

2.54

1.11–5.81

0.027

3.17

1.25–8.03

0.015

Anti-centromere antibody

3.53

1.42–8.77

0.006

3.39

0.97–11.90

0.057

Anti-dsDNA antibody

0.43

0.19–0.98

0.044

0.28

0.11–0.75

0.011

Arthritis

0.54

0.21–1.44

0.219

   

D-dimer (≥ 1.56 mg/L)

2.45

0.97–6.15

0.057

1.83

0.59–5.69

0.299

HCQ

0.35

0.16–0.74

0.006

0.56

0.23–1.35

0.197

Neuropsychiatric lupus

2.82

0.84–9.49

0.094

6.34

1.58–25.49

0.009

NT-proBNP

1.84

0.85–3.98

0.124

   

PTDs

0.62

0.30–1.30

0.208

   

Severe PASP (≥ 80 mmHg)

0.65

0.25–1.71

0.380

   

PDW

2.23

1.43–3.46

0.000

2.03

1.25–3.29

0.004

6MWD

1.00

0.99–1.00

0.001

1.00

0.99–1.00

0.074

LVEF (< 55%)

0.36

0.05–2.70

0.319

   

Thrombocytopenia

3.04

1.42–6.53

0.004

2.37

0.95–5.93

0.066

Thrombosis

3.31

0.99–11.02

0.052

2.39

0.55–10.27

0.243

Leukopenia

1.52

0.70–3.30

0.294

   
  1. Results are expressed as hazard ratio (95% confidence interval)
  2. Age and D-dimer were categorized by survival ROC cutoff value. Thrombocytopenia was defined as platelets < 100 × 109/L; leukopenia was defined as white blood cells < 3 × 109/L
  3. *P-value < 0.05 is shown in bold