Anti-Ro52 positivity is associated with progressive interstitial lung disease in systemic sclerosis—an exploratory study

Table 3 Predictive significance of patient characteristics on vital capacity

	Antibody presence			Antibody concentration
Predictors	Β	CI	p	Β	CI	p
Intercept^a	78.9	64.9 – 92.5	< 0.001	77.6	64.4 – 90.8	< 0.001
Follow-up time (years)^a	1.23	0.03 – 2.42	0.045	1.10	0.12 – 2.09	0.029
Change in baseline %predicted vital capacity at the time of SSc diagnosis
No immunomodulator use^bd	11.3	-6.01 – 28.6	0.195	11.0	-5.95 – 28.0	0.197
Female sex^b	12.7	-1.43 – 26.8	0.077	13.4	-0.21 – 27.0	0.053
dcSSc^b	0.91	-11.4 – 13.2	0.882	3.2	-9.22 – 15.7	0.604
Anti-Scl-70^b	-12.6	-25.0 – -0.29	0.045	-0.08	-0.15 – -0.01	0.032
Anti-Ro52^b	-1.25	-14.1 – 11.6	0.844	0.01	-0.09 – 0.11	0.864
Predicted change in %predicted vital capacity over time
No immunomodulator use * years^cd	-2.33	-4.87 – 0.20	0.070	-1.68	-3.99 – 0.63	0.149
dcSSc * years^c	-0.35	-2.14 – 1.43	0.691	-0.06	-1.73 – 1.61	0.944
Anti-Scl-70 * years^c	-1.07	-2.86 – 0.71	0.230	-0.00	-0.01 – 0.01	0.483
Anti-Ro52 * years^c	-2.41	-4.28 – -0.54	0.013	-0.03	-0.05 – -0.02	< 0.001

Predicted change in percentage of predicted vital capacity in patients with SSc-ILD, by patient characteristic, according to antibody presence and concentration. Presence of anti-Scl-70 predicted lower lung function at the time of diagnosis. Presence of anti-Ro52 autoantibody predicted significant decline of vital capacity over time in patients diagnosed with SSc-ILD. Higher anti-Ro52 concentration predicted significant decline of vital capacity over time in patients diagnosed with SSc-ILD
^aAlso included as random effects
^bTime independent effect (%pVC at baseline)
^cTime dependent effect (change in %pVC per year)
^duse ever of mycophenolic acid, cyclophosphamide, rituximab, tocilizumab, nintedanib, azathioprine, methotrexate, tumor necrosis factor inhibitors; ILD, interstitial lung disease; Β, regression coefficient; CI, confidence interval; dcSSc, diffuse cutaneous systemic sclerosis; ICC, intraclass correlation coefficient
^*indicates interaction term; P-values calculated using Kenward-Roger approximation of degrees of freedom

ISSN: 1478-6362