Skip to main content
Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway

Fig. 6

Osteoblastogenic effects of PDGFB. A Protein expression of GRB2 in FOB1.19 cells and ADSCs. Western blotting was performed under the same conditions (equal exposure time and dose). B Top pathway enrichment in the KEGG database in FOB1.19 cells. C Collagen expression of FOB1.19 in the two groups (PDGFB − , PDGFB +). D Relative protein level of collagen expression in FOB1.19 in the two groups (PDGFB − , PDGFB +). E, F Western blot of the collagen expression and RUNX2 with/without the treatments of PDGFB and si-RUNX2. G Possible mechanism of PDGFB pathogenesis in AS. The relative protein levels were compared by unpaired sample t-tests. * P < 0.05

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us