Fig. 1
From: Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
ATO alleviates inflammatory cell infiltration in the lung of Fra-2 transgenic mice. A Top: representative lung sections stained by hematoxylin and eosin. (magnification × 8). Bottom: histological lung fibrosis score (Ashcroft scale). B Top: representative IHC staining of T cells (CD3 +), macrophages (CD68 +), and neutrophils (Ly6G +) on 4-μm-thick lung section counterstained with hematoxylin (magnification: left × 10; right × 100). Bottom: Count number of CD3, CD68, and LY6G cells. Fra-2.TG mice were divided into 2 groups: PBS group (n = 11) and ATO group (n = 11). Values are represented by plot; bars represent the median with interquartile range. Statistics are from Mann-Whitney U test * = p < 0.05; ** = p < 0.01; *** = p < 0.001