Fig. 2
From: Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
Evaluation of ATO effects on various lung fibrosis outcome measures. A Content of collagen in a lung fragment assessed by hydroxyproline assay. B Left: representative SHG images of 16-μm-thick lung sections (magnification × 25); Right: scoring of fibrillar collagen in lung section assessed by SHG. C Lung density at microcomputed tomography (micro-CT). D Residual lung volume, expressed as the percentage of functional residual capacity. E Representative micro-CT images. Fra-2TG mice were divided into 2 groups: PBS-treated mice (n = 11) and ATO-treated mice (n = 11). Values are represented by plot; bars represent the median with interquartile range. Statistics are from Mann-Whitney U test. ns = not significant