Fig. 3
From: Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
ATO alleviates pulmonary hypertension in Fra-2 transgenic mice. A Right ventricular systolic pressure (RVSP). B Percentage of medial wall thickness. C Percentage of distal artery muscularization. D Top: representative images of hematoxylin and eosin staining. Bottom: representative images of a smooth muscle actin (αSMA). E Representative images of a smooth muscle actin (αSMA). Fra-2TG mice were divided into 2 groups: PBS group (n = 11) and ATO group (n = 11). Values are represented by plot; bars represent the median with interquartile range. Statistics are from Mann-Whitney U test. * = p < 0.05; ** = p < 0.01