Fig. 4
From: Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
ATO decreased T-cell activation in Fra-2 Tg lung cells. A Frequencies of CD69 + and PD1 + cells within CD4 + subset in lungs. B Frequencies of CD69 + and PD1 + cells within CD8 + subsets in lungs. C Frequencies of CD4 + effector memory T cells (TEM CD62L-CD44 +), central memory T cells (TCM: CD62L + CD44 +), and percentage of naive T cells (CD62L + CD44-) in lungs of both treated groups. D Frequencies of CD8 + effector memory T cells (TEM CD62L-CD44 +), central memory T cells (TCM: CD62L + CD44 +), and percentage of naive T cells (CD62L + CD44-) in lungs of both treated groups. Flow cytometry analysis was performed on 11 lungs from the PBS group and 11 lungs from ATO-treated Fra-2TG mice. Values are represented by plot; bars represent the median with interquartile range. Statistics are from Mann-Whitney U test. * = p < 0.05; ** = p < 0.01; *** = p < 0.001; ns = not significant