Fig. 5
From: Arsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis
Lung RNA-seq data analysis. A Volcano plot representation of differential expression analysis of genes from ATO-treated lungs vs. PBS-treated lungs. Green and red dots mark the genes with significantly decreased and increased expression, respectively. The x-axis shows log2 fold-changes in expression and the y-axis the p-value (log10) of a gene being differentially expressed. Corrected p-value of 0.05 and absolute foldchange of 2 were set as the threshold. B Top 100 differentially expressed genes. The heatmap illustrates the 50 most highly upregulated genes (red) and downregulated genes (blue) in lungs from ATO-treated group (n = 10) (left) and PBS group (n = 10) (right). C GO analysis of genes downregulated in lungs for biological process. Y-axis label represents the pathway, and X-axis label represents the gene ratio (gene ratio = gene numbers annotated in this pathway term/all gene numbers annotated in this pathway term). The size of the bubble represents the number of genes enriched in the GO terms, and the color shows the padj value of GO terms