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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling

Fig. 3

Candidate biomarkers based on the screening of 1000 proteins were selected for further validation. A Venn diagram depicted concordant proteins in DEPs from control VS SLE, control VS NPSLE, and SLE VS NPSLE. B Heatmap of 29 intersected proteins clustered by patients’ groups in the 1000-plexed proteins array. C PPI network of 29 proteins and derived proteins visualized by Cytoscape, with red indicating 29 proteins (no-interaction proteins were deleted) and green indicating derived proteins. D Key proteins were shown by the algorithm of Maximal Clique Centrality in Cytohubba. The darker the node, the higher the score

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