Novel CSF biomarkers for diagnosis and integrated analysis of neuropsychiatric systemic lupus erythematosus: based on antibody profiling

Table 1 Correlation analysis of CSF potential biomarkers versus clinical indicator

Spearman	TCN2	CST6	KLK5	L-selectin	Trappin-2
SLEDAI	−0.13	0.36**	−0.19	0.21	0.08
CSF IgG	−0.05	0.34*	−0.22	0.57****	0.36*
CSF albumin	−0.10	0.29*	−0.07	0.31*	0.22
Serum IgG	0.39**	−0.29	−0.11	−0.10	−0.25
Serum albumin	0.04	−0.02	−0.01	0.02	−0.02
C3	0.02	0.05	0.32*	0.12	0.12
C4	0.18	0.04	0.26	0.13	0.11
WBC	−0.22	−0.15	−0.13	−0.10	−0.08
NEUT	−0.31*	−0.17	−0.04	−0.23	−0.10
LYM	−0.15	−0.14	−0.13	−0.03	−0.09

Spearman analysis was used to analyze the correlation of 5 CSF proteins (TCN2, CST6, KLK5, L-selectin, Trappin-2) with clinical indexes in the independent cohort
WBC white blood cell count, NEUT neutrophil count, LYM lymphocyte
A p-value < 0.05 is considered statistically significant. *P<0.05; **P<0.01; ****P<0.0001

ISSN: 1478-6362