Fig. 2

Correlation between abundance of CRAMP, S100A8, and S100A9 in the joints with circulating serum levels of TNFα, IFNγ, and MCP-1 in the serum. The abundance of CRAMP, S100A8, and S100A9 in the joints were determined by western blot densitometry. The serum levels of TNFα, IFNγ, and MCP-1 was determined by Meso Scale Discovery platform. The GraphPad Prism 9 software was used for statistical analyses. Pearson’s correlation analysis was performed to determine the correlation between the abundance of each of the peptides in the joints with the levels of TNFα, IFNγ, and MCP-1 in the serum. Each data point represents a single mouse, from n = 7 per group; saline control (○), CIA mice (●), CIA mice with CUR (□), and CUR alone (Δ)