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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics

Fig. 1

The roles of writers, erasers, and readers in the m6A modification of mRNA. The dynamic process of RNA adenine methylation is driven by three major groups of enzymes called writers, erasers, and readers, which are responsible, respectively, for methylation, demethylation, and decoding of the methylation code. The m6A methylation process is catalyzed by a writer complex, which includes METTL3, METTL14, METTL16, WTAP, VIRMA, RBM15/15B, CBLL1, KIAA1429, and ZC3H13. The m6A eraser demethylases include FTO and ALKBH5. The m6A readers are proteins that recognize and bind to m6A marks, affecting the fate and function of the modified RNAs. The known m6A readers are YTHDF1/2/3, YTHDC1/2, IGF2BP1/2/3, and HNRNPC/A2B1

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Arthritis Research & Therapy

ISSN: 1478-6362

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