Table 1 The regulators involved in m6A methylation
Category | Genes | Function |
|---|---|---|
Writers | METTL3, METTL14, WTAP, KIAA1492 | METTL3 and METTL14 form complexes that catalyze the m6A methylation of RNA with WTAP and other factors such as KIAA1429. |
Erasers | FTO, ALKBH5 | The m6A modified base is demethylated by FTO and ALKBH. |
Readers | YTHDC1, YTHDC2, YTHDF1, YTHDF2, YTHDF3 | Recognizing RNA methylation modification information, participating in downstream RNA translation, degradation, and other processes. |