Table 1 Details of cancers and risk factors used in the study
From: Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study
Trait | Consortium | N. cases | N. controls | Sample size | Year | GWAS ID | F-statistics |
|---|---|---|---|---|---|---|---|
Overall breast cancer | BCAC | 122,977 | 105,974 | 228,951 | 2017 | ieu-a-1126 | 25693 |
Luminal A-like breast cancer | BCAC | 7325 | 20,815 | 28,140 | 2020 | NA | 17901 |
Luminal B/HER2- positive-like breast cancer | BCAC | 1682 | 20,815 | 22,497 | 2020 | NA | 13001 |
Luminal B/HER2- negative-like breast cancer | BCAC | 1779 | 20,815 | 22,594 | 2020 | NA | 3052 |
HER2-enriched-like breast cancer | BCAC | 718 | 20,815 | 21,533 | 2020 | NA | 2057 |
Triple-negative breast cancer | BCAC | 2006 | 20,815 | 22,821 | 2020 | NA | 2054 |
Overall lung cancer | ILCCO | 11,348 | 15,861 | 27,209 | 2014 | ieu-a-966 | 25617 |
Lung adenocarcinoma | ILCCO | 3442 | 14,894 | 18,336 | 2014 | ieu-a-965 | 11397 |
Squamous cell lung cancer | ILCCO | 3275 | 15,038 | 18,313 | 2014 | ieu-a-967 | 33778 |
Prostate cancer | UK Biobank | 9132 | 173,493 | 182,625 | 2021 | ieu-b-4809 | 52234 |
Endometrial cancer | O’Mara et al | 12,906 | 108,979 | 121,885 | 2018 | ebi-a-GCST006464 | 33778 |
Lymphomas | UK Biobank | 1752 | 359,442 | 361,194 | 2018 | ukb-d-C_LYMPHOMA | 302 |
Liver and bile duct cancer | UK Biobank | 350 | 372,016 | 372,366 | 2021 | ieu-b-4915 | 868 |
Cancer of urinary tract | UK Biobank | 1841 | 359,353 | 361,194 | 2018 | ukb-d-C_URINARY_TRACT | 86001 |
Thyroid cancer | Köhler et al | 649 | 431 | 1080 | 2013 | ieu-a-1082 | 47320 |
Oral cavity and pharyngeal cancer | Oncoarray oral cavity and oropharyngeal cancer | 2497 | 2928 | 5425 | 2016 | ieu-b-89 | 53769 |
Years of schooling | SSGAC | NA | NA | 766,345 | 2018 | ieu-a-1239 | 34289 |
Cigarettes per day | GSCAN | NA | NA | 337,334 | 2019 | ieu-b-25 | 2870 |
Alcoholic drinks per week | GSCAN | NA | NA | 335,394 | 2019 | ieu-b-73 | 2294 |
Body mass index | Neale Lab | NA | NA | 336,107 | 2017 | ukb-a-248 | 2304 |