Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study

Jia, Yiwei; Yao, Peizhuo; Li, Jia; Wei, Xinyu; Liu, Xuanyu; Wu, Huizi; Wang, Weiwei; Feng, Cong; Li, Chaofan; Zhang, Yu; Cai, Yifan; Zhang, Shuqun; Ma, Xingcong

doi:10.1186/s13075-023-03157-w

Arthritis Research & Therapy

Table 3 The results of heterogeneity analysis for SS on cancers

From: Causal associations of Sjögren’s syndrome with cancers: a two-sample Mendelian randomization study

Cancer types	Cochran’s Q test			IVW (random)
Cancer types	Method	Q	Q pval	OR (95% CI)	P value
Overall breast cancer	MR Egger	64.3370	1.94E − 10	0.9952 (0.9649, 1.0264)	0.7595
Overall breast cancer	IVW	65.1903	3.73E − 10
Luminal A-like breast cancer	MR Egger	27.1406	0.0013	1.0103 (0.9761, 1.0457)	0.5597
Luminal A-like breast cancer	IVW	27.1431	0.0025
Luminal B/HER2-positive-like breast cancer	MR Egger	16.4500	0.0581	NE	NE
Luminal B/HER2-positive-like breast cancer	IVW	17.3952	0.0661
Luminal B/HER2-negative-like breast cancer	MR Egger	9.9122	0.3576	NE	NE
Luminal B/HER2-negative-like breast cancer	IVW	10.6899	0.3822
HER2-enriched-like breast cancer	MR Egger	8.2534	0.5088	NE	NE
HER2-enriched-like breast cancer	IVW	8.6417	0.5664
Triple-negative breast cancer	MR Egger	8.9561	0.4413	NE	NE
Triple-negative breast cancer	IVW	8.9662	0.5353
Overall lung cancer	MR Egger	13.2712	0.1029	NE	NE
Overall lung cancer	IVW	13.2712	0.1507
Lung adenocarcinoma	MR Egger	9.8468	0.2759	NE	NE
Lung adenocarcinoma	IVW	9.8716	0.3610
Squamous cell lung cancer	MR Egger	19.2431	0.0136	1.0343 (0.9198, 1.1631)	0.5731
Squamous cell lung cancer	IVW	22.0099	0.0088
Prostate cancer	MR Egger	8.7033	0.3679	NE	NE
Prostate cancer	IVW	15.8168	0.0708
Endometrial cancer	MR Egger	12.0095	0.2844	NE	NE
Endometrial cancer	IVW	19.0442	0.0603
Lymphomas	MR Egger	29.8692	0.0009	1.0010 (1.0005, 1.0015)	0.0002
Lymphomas	IVW	34.6995	0.0003
Liver and bile duct cancer	MR Egger	3.9196	0.8643	NE	NE
Liver and bile duct cancer	IVW	3.9221	0.9165
Cancer of urinary tract	MR Egger	18.8126	0.0427	0.9996 (0.9992, 1.0000)	0.0281
Cancer of urinary tract	IVW	19.0671	0.0599
Thyroid cancer	MR Egger	8.2245	0.3132	NE	NE
Thyroid cancer	IVW	8.9707	0.3448
Oral cavity and pharyngeal cancer	MR Egger	20.4960	0.0086	1.1068 (0.9445, 1.2970)	0.2098
Oral cavity and pharyngeal cancer	IVW	25.2313	0.0027

Abbreviations: CI confidence interval, IVW inverse variance weighted, MR Mendelian randomization, NE not estimate, OR odds ratio, SS Sjögren’s syndrome

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