Fig. 2
From: Dual inhibition of glycolysis and glutaminolysis for synergistic therapy of rheumatoid arthritis
Expression of HK2 and GLS is associated with differential gene expression in fibroblasts. A, B Segregation of synovial STIA fibroblasts into Gls-positive, Hk2-positive, double-negative, and double-positive. C Proportion of Gls-positive, Hk2-positive, double-negative, and double-positive cells in STIA fibroblasts. Each dot represents a sample. Statistical significance was completed using one-way ANOVA and Turkey’s post hoc test. *: p < 0.05, **: p < 0.01, ***: p < 0.001, ****: p < 0.0001. D Heatmap of differentially expressed genes in Gls-positive, Hk2-positive, double-negative, or double-positive cells compared to all other cells. Expression is an average scaled expression of genes with an adjusted P value of < 0.01. E GO term enrichment in Gls-positive, Hk2-positive, double-negative, or double-positive fibroblasts. F Expression of selected marker genes in Gls-positive, Hk2-positive, double-negative, or double-positive fibroblasts from synovial STIA fibroblasts. G Expression of selected marker genes in GLS-positive, HK2-positive, double-negative, or double-positive fibroblasts from [25]